Representative Publications

  • Scalable secondary metabolite production in Streptomyces using a plug-and-play system. Nature Biotechnology. 2025-08. DOI: 10.1038/s41587-025-02762-1.
  • High-yield Porphyrin Production through Metabolic Engineering and Biocatalysis. Nature Biotechnology. 2024-06. DOI: 10.1038/s41587-024-02267-3.
  • Model-Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132. Advanced Science, 2025-09. DOI:10.1002/advs.202511411.
  • G2 Helix as the Plastic Region Modulating Diastereoselectivity of Cyclization in Fungal Bifunctional Sesterterpene Synthases. ACS Catalysis. 2025-07. DOI: 10.1021/acscatal.5c03947.
  • Expanding horizons of CRISPR applications beyond genome editing. Trends in Genetics. 2025-07. DOI: 10.1016/j.tig.2025.06.003.
  • Cytochrome P450-Catalyzed Tetrahydrofuran Formation via Dual Pathways in Avermectin Biosynthesis. ACS Catalysis. 2025-02. DOI: 10.1021/acscatal.4c06900.
  • Taming Highly Enolizable Aldehydes via Enzyme Catalysis for Enantiocomplementary Construction of β-Hydroxyphosphonates. Journal of the American Chemical Society. 2025-01. DOI: 10.1021/jacs.4c11957.
  • Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization. ACS Catalysis. 2025-01. DOI: 10.1021/acscatal.4c06881.
  • Systematic Development of a Highly Efficient Cell Factory for 5-Aminolevulinic Acid Production. Trends in Biotechnology. 2024-11. DOI: 10.1016/j.tibtech.2024.06.004.
  • Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS. Angewandte Chemie International Edition. 2024-09. DOI: 10.1002/anie.202406246.
  • Unleashing the Potential: Type I CRISPR-Cas Systems in Actinomycetes for Genome Editing. Natural Product Reports. 2024-06. DOI: 10.1039/D4NP00010B.
  • Biochemical and Structural Characterization of OvoATh2: A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. ACS Catalysis. 2023-11. DOI: 10.1021/acscatal.3c04026.
  • A Thermostable Type IB CRISPR-Cas System for Orthogonal and Multiplexed Genetic Engineering. Nature Communications. 2023-10. DOI: 10.1038/s41467-023-41973-5.
  • Hydrogenase as the Basis for Green Hydrogen Production and Utilization. Journal of Energy Chemistry. 2023-10. DOI: 10.1016/j.jechem.2023.06.018.
  • Profile and Relaxation of Sequence-Specificity of DNA Sulfur Binding Domains Facilitate New Nucleic Acid Detection Platform. Science Bulletin. 2023-08. DOI: 10.1016/j.scib.2023.07.012.
  • Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity. Advanced Science. 2022-03. DOI: 10.1002/advs.202104871.
  • Activating Cryptic Biosynthetic Gene Cluster through a CRISPR–Cas12a-Mediated Direct Cloning Approach. Nucleic Acids Research. 2022-03. DOI: 10.1093/nar/gkac181.
  • Berberine Reverses Multidrug Resistance in Candida Albicans by Hijacking the Drug Efflux Pump Mdr1p. Science Bulletin. 2021-09. DOI: 10.1016/j.scib.2020.12.035.
  • Anti-Mycobacterial Natural Products and Mechanisms of Action. Natural Product Reports. 2021-07. DOI: 10.1039/D1NP00011J.
  • A Versatile Biosensing Platform Coupling CRISPR–Cas12a and Aptamers for Detection of Diverse Analytes. Science Bulletin. 2021-01. DOI: 10.1016/j.scib.2020.09.004.
  • Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis. ACS Central Science. 2020-05. DOI: 10.1021/acscentsci.0c00122.
  • Harnessing the Intracellular Triacylglycerols for Titer Improvement of Polyketides in Streptomyces. Nature Biotechnology. 2019-12. DOI: 10.1038/s41587-019-0335-4.
  • Visualizing RNA Dynamics in Live Cells with Bright and Stable Fluorescent RNAs. Nature Biotechnology. 2019-09. DOI: 10.1038/s41587-019-0249-1.
  • A CRISPR-Cas12a-Derived Biosensing Platform for the Highly Sensitive Detection of Diverse Small Molecules. Nature Communications. 2019-08. DOI: 10.1038/s41467-019-11648-1.
  • Harnessing a Previously Unidentified Capability of Bacterial Allosteric Transcription Factors for Sensing Diverse Small Molecules in Vitro. Science Advances. 2018-11. DOI: 10.1126/sciadv.aau4602.